RESEARCH ON THE EFFECT OF THE MOLECULAR WEIGHT OF HYALURONIC ACID ON THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE MATERIAL
DOI:
https://doi.org/10.35546/kntu2078-4481.2025.3.1.14Keywords:
watering method, hyaluronic acid, modified starch, gelatin, transdermal therapeutic systemsAbstract
This work aimed to study the effect of the molecular weight of hyaluronic acid on the structural and functional properties of the material in the form of films. The polymer composition was selected as a mixture of modified starch, gelatin, and hyaluronic acid with different molecular weights. The research was conducted by obtaining polymer films based on carboxymethylated starch/gelatin compositions in ratios (50/50) with the addition of 1.0 % hyaluronic acid (low molecular weight, medium molecular weight, and high molecular weight). The work experimentally established the rheological dependence of viscosity on shear rate and investigated the kinetics of water absorption. The films were obtained from solutions of the polymer composition by pouring and drying at room temperature, followed by a study of their physical and mechanical properties and potential for use in transdermal systems. The results of the studies showed that samples with the addition of hyaluronic acid had 5–10 % higher sorption properties, swelling rate, and 3–5 % lower physical and mechanical properties than samples obtained based on modified starch/gelatin. The films obtained had mechanical strength, did not break during application and use, and completely retained their integrity. The scientific novelty of the work lies in the fact that, for the first time, a comparative study was conducted on the effect of the molecular weight of hyaluronic acid on the properties of films based on carboxymethylated starch/gelatin to improve the functionality of films as moisturisers or carriers for transdermal systems. This opens up new opportunities for optimising production processes. The study’s practical significance lies in expanding the range of carriers of active pharmaceutical ingredients for transdermal therapeutic systems on the modern market by offering a new product. The results obtained create a basis for further optimizing the composition of biopolymer films to develop new, effective biocompatible materials for medicine and pharmaceuticals.
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