APPLICATION OF ELECTROSPINNING AND CENTRIFUGAL FIBRE FORMATION TECHNOLOGIES TO CREATE HIGHLY SOLUBLE SOLID DISPERSED SYSTEMS CONTAINING ACTIVE PHARMACEUTICAL INGREDIENTS
DOI:
https://doi.org/10.35546/kntu2078-4481.2025.1.1.2Keywords:
solid dispersed systems, centrifugal fibre formation, electrospinning, active pharmaceutical ingredient, methods of increasing solubility, polymers, polyvinylpyrrolidoneAbstract
This paper presents the results of a comprehensive analysis of scientific and literary sources devoted to the characterisation of electrospinning and centrifugal fibre formation methods, as well as trends in their use for the production of highly soluble solid dispersed systems (SDSs) containing active pharmaceutical ingredients (APIs). Low solubility is one of the key problems that limit the bioavailability of a significant number of APIs, so the development of effective strategies to improve it is an important area of modern chemical and pharmaceutical research. The technology of forming solid dispersed systems, in which APIs are dispersed in a polymer matrix, is considered a promising approach to solving this problem. Currently, there is a growing research interest in the methods of forming solid dispersed systems in the form of fibres. It has been established that the technologies of electrospinning and centrifugal fibre formation are gaining popularity in scientific circles and industry. Electrospinning involves the use of an electrostatic field to draw a polymer solution or melt into sub-micron or nanometre diameter fibres. This method provides the ability to control the morphological characteristics of the fibres, but has certain limitations due to the scale of the process and the need for high voltages. The centrifugal fibre forming process uses centrifugal force to generate fibres from polymer solutions or melts containing APIs. This method is characterised by potential advantages such as high productivity, reduced energy consumption and the use of relatively simple equipment. According to the analysis of scientific and literary sources, it has been proved that both methods are now widely used in the creation of fibrous SDS with improved solubility of APIs of various pharmacological groups. The choice between electrospinning and centrifugal fibre formation depends on the specific requirements for the morphology of the SDS fibres, their mechanical properties, as well as on the production scale and economic considerations.
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